Biglycan potentially regulates angiogenesis during fracture repair by altering expression and function of endostatin
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چکیده
منابع مشابه
Endostatin binds biglycan and LDL and interferes with LDL retention to the subendothelial matrix during atherosclerosis.
Retention of lipoproteins to proteoglycans in the subendothelial matrix (SEM) is an early event in atherosclerosis. We recently reported that collagen XVIII and its proteolytically released fragment endostatin (ES) are differentially depleted in blood vessels affected by atherosclerosis. Loss of collagen XVIII/ES in atherosclerosis-prone mice enhanced plaque neovascularization and increased the...
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Endostatin is a well-known angiogenesis inhibitor. Although angiogenesis has been considered as a potential therapeutic target of obesity, the inhibitory effect of endostatin on adipogenesis and dietary-induced obesity has never been demonstrated. Adipogenesis plays a critical role in controlling adipocyte cell number, body weight, and metabolic profile in a homeostatic state. Here we reveal th...
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ژورنال
عنوان ژورنال: Matrix Biology
سال: 2016
ISSN: 0945-053X
DOI: 10.1016/j.matbio.2016.03.008